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            當前位置:首頁技術(shù)文章WWP1抗原,WW結(jié)構(gòu)域E3泛素連接酶1抗原

            WWP1抗原,WW結(jié)構(gòu)域E3泛素連接酶1抗原

            更新時間:2024-11-08點擊次數(shù):75

            Recombinant human WWP1   

            AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.          

            濃度:1mg/ ml

            來源:Recombinant Human

            純度:≥95% SDS-PAGE

            表達系統(tǒng):Escherichia coli

            標簽:His tag   

            蛋白長度:Full length protein

            內(nèi)毒素水平:<1.000 Eu/µg

            純化方法:HPLC

            應(yīng)用:SDS-PAGEWestern blotELISA

            Biological activity,immunology research

            保存:-20

            保質(zhì)期:1

            WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.



            多克隆抗體

            產(chǎn)品名稱:Rabbit Anti-WWP1 antibody

            Rabbit Anti-WWP1 

            別名:AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.             

            來源:Rabbit

            克隆類型:Polyclonal

            濃度:1mg/ml

            亞型:IgG

            反應(yīng):Rat (predicted: Human,Mouse,Rabbit,Sheep,Cow,Dog,Horse)

            應(yīng)用: WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

            理論分子量:105kDa

            免疫原:KLH conjugated synthetic peptide derived from human WWP1

            保存:-20
            保質(zhì)期:1

             

             單克隆抗體

            產(chǎn)品名稱:Anti-WWP1 antibody

            Mouse Anti-WWP1

            別名:AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.                

            來源:Mouse

            克隆類型:Monoclonal

            濃度:1mg/ml

            亞型:IgG

            反應(yīng):Human

            應(yīng)用: WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500  

            反應(yīng):  Human

            理論分子量:105kDa

            免疫原:KLH conjugated synthetic peptide derived from human WWP1

            保存:-20
            保質(zhì)期:1

            WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.

             

             


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