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            當(dāng)前位置:首頁(yè)技術(shù)文章WIF1抗原,Wnt信號(hào)抑制因子1抗原

            WIF1抗原,Wnt信號(hào)抑制因子1抗原

            更新時(shí)間:2024-11-13點(diǎn)擊次數(shù):75

            Recombinant human WIF1   

            WIF-1; wif1; WIF1_HUMAN; Wnt Inhibitory Factor 1.  

            濃度:1mg/ ml

            來(lái)源:Recombinant Human

            純度:95% SDS-PAGE

            表達(dá)系統(tǒng):HEK 293 cells

            標(biāo)簽:His tag C-Terminus   

            蛋白長(zhǎng)度:Full length protein

            內(nèi)毒素水平:<1.000 Eu/µg

            純化方法:HPLC

            應(yīng)用:SDS-PAGEWestern blotELISA

            Biological activity,immunology research

            保存:-20

            保質(zhì)期:1

            The Wnt genes are a group of conserved, Cysteine-rich, secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. Wnt association with the transmembrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation. Reduced levels of active GSK causes accumulation of b-catenin and subsequent regulation of developmentally significant Wnt target genes. Wnt antagonists such as dickkopf (Dkk), frizzled-related protein (sFRP) and Wnt inhibitory factor-1 (WIF-1), are necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes. WIF-1 is a 379-amino acid secreted protein that contains an N-terminal signal sequence, a 150-amino acid WIF domain, five epidermal growth factor-like repeats and a 45-amino acid C-terminal hydrophilic domain.



            產(chǎn)品名稱:Rabbit Anti-WIF1 antibody

            Rabbit Anti-WIF1 

            別名:WIF-1; wif1; WIF1_HUMAN; Wnt Inhibitory Factor 1.              

            來(lái)源:Rabbit

            克隆類型:Polyclonal

            濃度:1mg/ml

            亞型:IgG

            反應(yīng):(predicted: Human,Mouse,Rat,Pig,Cow,Chicken,Dog,Horse)

            應(yīng)用: WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

                   IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

            理論分子量:39kDa

            免疫原:KLH conjugated synthetic peptide derived from human WIF1

            保存:-20
            保質(zhì)期:1

             

             

            產(chǎn)品名稱:Anti-WIF1 antibody

            Mouse Anti-WIF1

            別名:WIF-1; wif1; WIF1_HUMAN; Wnt Inhibitory Factor 1.                 

            來(lái)源:Mouse

            克隆類型:Monoclonal

            濃度:1mg/ml

            亞型:IgG

            反應(yīng):Human

            應(yīng)用:WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

                   IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

            反應(yīng):  Human

            理論分子量:39kDa

            免疫原:KLH conjugated synthetic peptide derived from human WIF1

            保存:-20
            保質(zhì)期:1

            The Wnt genes are a group of conserved, Cysteine-rich, secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. Wnt association with the transmembrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation. Reduced levels of active GSK causes accumulation of b-catenin and subsequent regulation of developmentally significant Wnt target genes. Wnt antagonists such as dickkopf (Dkk), frizzled-related protein (sFRP) and Wnt inhibitory factor-1 (WIF-1), are necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes. WIF-1 is a 379-amino acid secreted protein that contains an N-terminal signal sequence, a 150-amino acid WIF domain, five epidermal growth factor-like repeats and a 45-amino acid C-terminal hydrophilic domain.


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